Hrabinová Martina

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PhD student
+420 973 255 193
martina.hrabinova@unob.cz
ORCID: 0000-0002-9428-4109

Martina získala titul Mgr. v roce 2014 na Farmaceutické fakultě v Hradci Králové, Univerzity Karlovy v Praze. Hlavním cílem její diplomové práce byl vývoj metod pro in vitro testování potenciálních léčiv Alzheimerovy choroby. V současné době je postgraduální studentkou na Katedře toxikologie, Fakulty vojenského zdravotnictví, Univerzity obrany, kde se zabývá expresí a purifikací rekombinantních proteinů a vývojem biochemických metod pro látky ovlivňující centrální nervový systém.

Vzdělání

Odborné zaměření

Testování (in vitro a in vivo) nově připravených reaktivátorů acetylcholinesterasy, sloužících jako ochrana před otravou nervově paralytickými látkami a pesticidy.

Testování (in vitro a in vivo) nově připravených inhibitorů acetylcholinesterasy, které jsou zapojeny v léčbě Alzheimerovy choroby a Myastenia Gravis.

Pracovní zkušenosti

2013–dosud výzkumný a vývojový pracovník PreSeed, Centrum biomedicínského výzkumu, Fakultní nemocnice Hradec Králové

2006–dosud laborantka, Univerzita obrany, Fakulta vojenského zdravotnictví, Centrum pokročilých studií

1996–2006 laborantka, Univerzita obrany, Fakulta vojenského zdravotnictví, katedry Toxikologie

1995–1992 laborantka Ekos a.s.

1992–1991 laborantka Bioanalytika s.r.o.

1991–1987 laborantka Agrochemický podnik

Publikační aktivita

 • Autor nebo spoluautor 349 vědeckých publikací v časopisech s IF

 • H-index: 12

 • počet citací bez autocitací: 361

(stav k 12/2016)

Vybrané publikace

2017

Gazova Z, Soukup O, Sepsova V, Siposova K, Drtinova L, Jost P, et al. Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment. Biochimica Et Biophysica Acta-Molecular Basis of Disease. 2017;1863:607-19. IF=5,158; cited 0x

Jerabek J, Uliassisi E, Guidottii L, Bartolini M, Peňa-Altamira L, Petralla S, Monti B, Roberti M, Bolognesi M, Korabecny J, Soukup O, Kuca K, Sepsova V, Hrabinova M. Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease. 2017; IF=3,18; cited 0x

2016

Vaneckova N, Hostalkova A, Safratova M, Kunes J, Hulcova D, Hrabinova M, Doskocil I,  et al. Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson and their biological activities. RSC Adv., 2016;6, 80114-80120. IF 3,289; cited 0x

Benek O, Soukup O, Pasdiorova M, Hroch L, Sepsova V, Jost P, et al. Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease. Chemmedchem. 2016;11:1264-9. IF=2,98; cited 2x

Hamulakova S, Poprac P, Jomova K, Brezova V, Lauro P, Drostinova L, et al. Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules. J InorgBiochem. 2016;161:52-62. IF=3,205; cited 1x

2014

Hamulakova S, Janovec L, Hrabinova M, Spilovska K, Korabecny J, Kristian P, Kuca K, Imrich J,   Synthesis and Biological Evaluation of Novel TacrineDerivates and Tacrine-Coumarin Hybrids as Cholinesterase Inhibitors. J. Med. Chem., 2014; 57 (16), 7073–7084. IF 5,447; cited 27x

2013

Cahlíková L, Hrabinová M, Kulhánková A, Benesová N, Chlebek J, Jun D, Novák Z, Macáková K, Kunes J, Kuca K, Opletal L. Alkaloids from Chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities. Nat Prod Commun. 2013 Nov;8(11):1541-4.

Bures J, Kvetina J, Pavlik M, Kunes M, Kopacova M, Rejchrt S, Jun D, Hrabinova M, Kuca K, Tachecí I. Impact of paraoxon followed by acetylcholinesterase reactivator HI-6 on gastric myoelectric activity in experimental pigs. Neuro Endocrinol Lett. 2013; 34 (2):79-83.

Komloova M, Horova A, Hrabinova M, Jun D, Dolezal M, Vinsova J, Kuca K,Musilek K. Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors. Bioorg Med Chem Lett. 2013; 23(24):6663-6.

Kuca K, Musilek K, Jun D, Karasova J, Soukup O, Pejchal J, Hrabinova M. Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX. Med Chem. 2013; 9(5):689-93.

2012

Hamulakova S, Janovec L, Hrabinova M, Kristian P, Kuca K, Banasova M, Imrich J. Synthesis, design and biological evaluation of novel highly potent tanine congeners for the treatment of Alzheimer's disease. Eur J Med Chem. 2012; 55:23-31.

Pohanka M, Hrabinova M, Fusek, J, Hynek D, Adam V, Hubálek J, Krizek R. Electrochemical Biosensor Based on Acetylcholinesterase and Indoxylacetate for Assay of Neurotoxic Compounds Represented by Paraoxon International J Electrochem Science 2012; 7(1): 50-57.

2011

Pohanka M, Hrabinova M, Zemek F, Drtinova L, Bandouchova H, Pikula J. Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model. Neuro Endocrinol Lett. 2011; 32(1):95-100.

Pohanka M, Novotny L, Zdarova-Karasova J, Bandouchova H, Zemek F, Hrabinova M, Misik J, Kuca K, Bajgar J, Zitka O, Cernei N, Kizek R, Pikula J. Asoxime (HI-6) impact on dogs after one and tenfold therapeutic doses: assessment of averse effects, distribution, and oxidative stress. Environ Toxicol Pharmacol. 2011; 32(1):75-81.

Pohanka M, Hrabinova M, Kuca K, Simonato JP. Assessment of Acetylcholinesterase Activity Using Indoxylacetate and Comparison with the Standard Ellman's Method. Int J Mol Sci. 2011; 12(4):2631-40.

Musilek K, Pavlikova R, Marek J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Dolezal M, Gunn-Moore F, Kuca K. The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage. J Enzyme Inhib Med Chem. 2011; 26(2):245-53.

Musilek K, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K. Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment. Eur J Med Chem. 2011; 46(2):811-8.

Musilek K, Roder J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Opletalova V, Kuca K, Jung YS. Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors-analogues of SAD-128. Bioorg Med Chem Lett. 2011; 21(1):150-4.

2010

Kuca K, Musilek K, Jun D, Pohanka M, Ghosh KK, Hrabinova M. Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. J Enzyme Inhib Med Chem. 2010; 25(4):509-12.

Musilek K, Komloova M, Zavadova V, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K, Jung YS. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications. Bioorg Med Chem Lett. 2010; 20(5):1763-6.

2009

Kuca K, Musilova L, Palecek J, Cirkva V, Paar M, Musilek K, Hrabinova M, Pohanka M, Karasova JZ, Jun D. Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. Molecules. 2009; 14(12):4915-21.

Kuca K, Cabal J, Jung YS, Musilek K, Soukup O, Jun D, Pohanka M, Musilova L, Karasová J, Novotný L, Hrabinova M. Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127. Basic Clin Pharmacol Toxicol. 2009; 105(3): 207-10.

Pohanka M, Novotný L, Misík J, Kuca K, Zdarova-Karasova J, Hrabinova M.

Evaluation of cholinesterase activities during in vivo intoxication using an electrochemical sensor strip - correlation with intoxication symptoms. Sensors. 2009; 9(5): 3627-34.

2008

Kuca K, Stodulka P, Hrabinova M, Hanusova P, Jun D, Dolezal B. Preparation of oxime HI-6 (dichloride and dimethanesulphonate)-antidote against nerve agents. Defence Science J. 2008; 58(3): 399-404.

Pohanka M, Hrabinova M, Kuca K. Diagnosis of intoxication by the organophosphate VX: Comparison between an electrochemical sensor and Ellman's photometric method. Sensors 2008; 8(9): 5229-5237.

2007

Kuca K, Marek J, Stodulka P, Musilek K, Hanusova P, Hrabinova M, Jun D. Preparation of benzalkonium salts differing in the length of a side alkyl chain. Molecules. 2007; 12(10):2341-7.

Kuca K, Musilek K, Paar M, Jun D, Stodulka P, Hrabinova M, Marek J. Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide-a new nerve agent reactivator. Molecules. 2007; 12(8):1964-72.

Kuca K, Cabal J, Jun D, Hrabinova M. Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin. Clin Toxicol (Phila). 2007; 45(5):512-5.