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Vedoucí skupiny
+420 495 833 885
kamil.musilek@fnhk.cz
doc. | (2012) | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, obor Farmaceutická chemie |
PharmDr. | (2008) | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, obor Farmaceutická chemie |
Ph.D. | (2007) | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, obor Farmaceutická chemie |
Mgr. | (2004) | Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové |
2011–dosud | vedoucí katedry, Univerzita Hradec Králové, Přírodovědecká fakulta, Katedra chemie |
2011–2018 | vedoucí laboratoře chemické syntézy, Centrum biomedicínského výzkumu, Fakultní nemocnice Hradec Králové |
2006–2011 | vedoucí laboratoře chemické syntézy, Univerzita obrany, Fakulta Vojenského zdravotnictví, Katedra toxikologie |
2004–2007 | Ph.D. student |
2009 | Centre Recherche Service Santé Armée, La Tronche/Grenoble, Francie (2 měsíce) |
2007 | University of St. Andrews, Skotsko (6 měsíců) |
2003–2004 | Ruprecht-Karls-Universität Heidelberg, Německo (5 měsíců) |
GA18-01734S (2018-2020), GA18-14259S (2018-2020), NV16-34390A (2016-2019), NV15-28967A (2015-2018), LD14009 (2014-2015), LH13009 (2013-2015), ME09086 (2009-2012), GP203/09/P130 (2009-2011), OVUOFVZ200805 (2008-2011)
Zarska, M.; Sramek, M.; Novotny, F.; Havel, F.; Babelova, A; Mrazkova, B.; Benada, O.; Reinis, M.; Stepanek, I.; Musilek, K.; Bartek, J.; Ursinyova, M.; Novak, O.; Dzijak, R.; Kuca, K.*; Proska, J.*; Hodny, Z.* Biological safety and tissue distribution of (16-mercaptohexadecyl)trimethylammonium bromide-modified cationic gold nanorods. Biomaterials 2018, vol. 154, no. 1, p. 275-290. DOI: 10.1016/j.biomaterials.2017.10.044. IF2016 = 8.402
Zdarova Karasova, J.*; Kvetina, J.; Tacheci, I.; Radochova, V.; Musilek, K.; Kuca, K.; Bures, J. Pharmacokinetic profile of promising acetylcholinesterase reactivators K027 and K203 in experimental pigs. Toxicology Letters 2017, vol. 273, no. 1, p. 20-25. DOI: 10.1016/j.toxlet.2017.03.017. IF2016 = 3.858
Benek, O.; Soukup, O.; Pasdiorova, M.; Hroch, L.; Sepsova, V.; Jost, P.; Hrabinova, M.; Jun, D.; Kuca, K.; Zala, D.; Ramsay, R.R.; Marco-Contelles, J.*; Musilek, K.* Design, synthesis and in vitro evaluation of indolotacrine analogues as multi-target-directed ligands for the treatment of Alzheimer’s disease. ChemMedChem, 2016, vol. 11, no. 12, p. 1264-1269. DOI: 10.1002/cmdc.201500383. IF2016 = 3.225
Horn, G.; Wille, T.; Musilek, K.; Kuca, K.; Thiermann, H.; Worek, F.* Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. Archives of Toxicology. 2015, vol. 89, no. 3, p. 405–414. DOI: 10.1007/s00204-014-1288-5. IF2015 = 6.637
Misik, J.*; Vanek, J.; Musilek, K.; Kassa, J. Cholinergic antagonist 3-quinuclidinyl benzilate; impact on learning and memory in Wistar rats. Behavioural Brain Research. 2014, vol. 266, no. 1, p. 193-200. DOI: 10.1016/j.bbr.2014.03.001. IF2014 = 3.028
Kalasz, H. – Szegi, P. – Janoki, G. – Balogh, L. – Postenyi, Z. – Musilek, K. – Petroianu, G.A. – Siddiq, A. - Tekes, K. Study on Medicinal Chemistry of K203 in Wistar Rats and Beagle Dogs. Current Medicinal Chemistry. 2013, 20(16), p. 2137-2144. DOI: 10.2174/0929867311320160006. IF2011 = 4.859
Worek, F. - von der Wellen. J. - Musilek, K. - Kuca, K. - Thiermann, H. Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase. Archives of Toxicology. 2012, 86(9), p. 1379-1386. DOI: 10.1007/s00204-012-0842-2. IF2011 = 4.674
Musilek, K. - Dolezal, M. - Gunn-Moore, F. - Kuca, K. Design, Evaluation and Structure-Activity Relationship Studies of the AChE Reactivators Against Organophosphorus Pesticides. Medicinal Research Reviews. 2011, 31(4), p. 548-575. DOI: 10.1002/med.20192. IF2011 = 10.700
Muirhead, K. E. A. - Froemming, M. - Li, X. G. - Musilek, K. - Conway, S. J. - Sames, D. - Gunn-Moore, F. J. (-)-CHANA, a Fluorogenic Probe for Detecting Amyloid Binding Alcohol Dehydrogenase HSD10 Activity in Living Cells. ACS Chemical Biology. 2010, 5(12), p. 1105-1114. DOI: 10.1021/cb100199m. IF2010 = 5.698
Jeong, H. C. - Park, N. J. - Chae, C. H. - Musilek, K. - Kassa, J. - Kuca, K. - Jung, Y. S. Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent. Bioorganic & Medicinal Chemistry. 2009, 17(17), p. 6213-6217. DOI: 10.1016/j.bmc.2009.07.043 IF2009 = 2.822
Musilek, K. - Jampilek, J. - Dohnal, J. - Jun, D. - Gunn-Moore, F. - Dolezal, M. - Kuca, K. RP-HPLC determination of the lipophilicity of bispyridinium reactivators of acetylcholinesterase bearing a but-2-ene connecting linker. Analytical and Bioanalytical Chemistry. 2008, 391(1), p. 367-372. DOI: 10.1007/s00216-008-2018-8. IF2008 = 3.328
Musilek, K. - Jun, D. - Cabal, J. - Kassa, J. - Gunn-Moore, F. - Kuca, K. Design of a potent reactivator of tabun-inhibited acetylcholinesterase-synthesis and evaluation of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide (K203). Journal of Medicinal Chemistry. 2007, 50(22), p. 5514-5518. DOI: 10.1021/jm070653r. IF2007 = 4.895
Musilek, K. - Kuca, K. - Jun, D. - Dohnal, V. - Dolezal, M. Synthesis of the novel series of bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against chlorpyrifos-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 2006, 16(3), p. 622-627. DOI:10.1016/j.bmcl.2005.10.059. IF2006 = 2.538
Fiammengo, R. - Musilek, K. - Jaschke, A. Efficient preparation of organic substrate-RNA conjugates via in vitro transcription. Journal of the American Chemical Society. 2005, 127(25), p. 9271-9276. DOI: 10.1021/ja051179m. IF2005 = 7.419