Title of project: | Targeted and Improved Alzheimer's Disease Drug Development |
Registration number: | TO01000078 |
Researchers: | assoc. prof. PharmDr. Ondřej Soukup Ph.D. |
Contact person: | Mgr. Dora Truncová |
Programme Operator: | Technology Agency of the Czech Republic |
Funded by: | EEA (European Economic Area)/ Norwegioan Funds, The state budget of the Czech Republic |
Principal Investigator: | University Hospital Hradec Králové |
Consortioum members: | University of Oslo - Prof. Dr. copper. Dr. rer. nat. Jens Pahnke E.F.N. |
Institute of Experimental Medicine AS CR, v.v.i. - Mgr. Martin Horák Ph.D. | |
Bioinova, s.r.o. - MUDr. Peter Bauer Ph.D. | |
Timetable: | 1.1.2021 – 30.4.2024 |
Total budget: | max. fund: 35.212.148 Kč |
85 % z Norway grants: 29.930.325 Kč | |
15 % TA CR: 5.281.823 Kč |
The aim of the project is the development of compounds for the treatment of Alzheimer´s disease (AD). The project will include an approaches of personalized medicine during the development process in the way that novel compounds will be tested in a disease in a dish (DiD) model derived from AD patients.
The Targeted and Improved Alzheimer's Disease Drug Development benefits from a € (amount - use a rounded figure) grant from Norway Grants and Technology Agency of the Czech Republic within the KAPPA Programme.)
On 21 November 2023, the Faculty of Science of the University of Hradec Králové organized a workshop with Prof. Pahnke from the University of Oslo focused on ABC transporters and their importance in the pathophysiology of neurodegenerative diseases.
Barbora Svobodová, MSc. participated in an international conference in Boston 10. – 13. 6. 2023 (ACSMEDI | EFMC Medicinal Chemistry Frontiers 2023, Boston, USA). The aim of the foreign trip was mainly to deepen knowledge in the field of medicinal chemistry and to implement these findings in the research of the CBV. Main part of the conference was various aspects of the development of new drugs with a wide range of applications - anti-tumor drugs, drugs for neurodegenerative diseases, antimicrobial drugs, etc. The results of research were presented in poster form „PHYSICOCHEMISTRY SHAPES BIOACTIVITY LANDSCAPE OF PAN-ABC TRANSPORTER MODULATORS: ANCHOR POINT FOR INNOVATIVE ALZHEIMER'S DISEASE THERAPEUTICS“.
Poster Boston 2023 | 1 064 kB |
TARIMAD Articles 2024 | 163 kB | |
TARIMAD Articles 2023_2 | 194 kB | |
TARIMAD Articles 2023 | 171 kB | |
TARIMAD Articles 2022_1 | 176 kB | |
TARIMAD Articles 2022_2 | 183 kB | |
TARIMAD Articles 2021 | 112 kB |