Kožurková Mária

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Visiting Professor
maria.kozurkova@upjs.sk
ORCID: 0000-0002-8344-0671

Maria obtained her degree as Professor in 2021 at the Pavol Jozef Šafárik University. Currently she is responsible for the investigation of interaction of new drugs with DNA by various techniques. Besides the scientific activity, Maria is devoted to the students supervising and teaching. She is study consultant for Biochemistry.

Education

Research Focus

Interaction of small molecules with biomolecules

Membership in Scientific Organizations and Councils

• Slovak Society for Biochemistry and Molecular Biology

• Member of the National selection committee CEEPUS (central European Exchange Programme for University Studies)

• Association of Chemistry Teachers

• Slovak Accreditation Agency for Higher Education - reviewer
  

Professional Training

Projects

Title: Štúdium latentného poškodenia pečene vyvolaného ožarovaním a chemickou noxou a hľadanie možností zmiernenia poškodenia podávaním hepatoprotektívnych látok.      

Founding: VEGA č. 1/239/92 Ministry of Education, Science, Research and Sport of the SR

Schedule: 1992–1995

Role: Other investigator

Title: Účinok kombinovaného pôsobenia genotoxických činiteľov životného prostredia na pečeň a obličky.

Founding: VEGA č. 3228/96 Ministry of Education, Science, Research and Sport of the SR

Schedule: 1996–1998

Role: Other investigator

Title: Účinok niektorých genotoxických činiteľov životného prostredia na pečeň a obličky.

Founding: VEGA č. 1/6030/99 Ministry of Education, Science, Research and Sport of the SR

Schedule: 1999–2001

Role: Other investigator

Title: Transgeneračný prenos poškodenia genómu spôsobeného genotoxickými faktormi životného prostredia.  

Founding: VEGA č. 1/6030/02 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2002–2004

Role: Other investigator

Title: Interaction of anticancer drugs with nucleic acids.

Founding: VEGA č. 1/1274/04 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2004–2006

Role: Other investigator

Title: Nestabilita genómu v mozgovom tkanive potomkov potkaních samcov exponovaných niektorými genotoxickými činiteľmi životného prostredia.

Founding: VEGA č. 1/2353/05 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2005–2007

Role: Other investigator

Title: Nové technológie vo výučbe chémie a biológie u žiakov základných a stredných škôl k trvalo udržateľnému rozvoju.

Founding: KEGA č. 3/3004/05 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2005–2007

Role: Other investigator

Title: Molecular design of new DNA binding anticancer and antibacterial drugs.

Founding: VEGA č. 1/3254/06 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2006–2008

Role: Other investigator

Title: Increasing of knowledge potential.

Founding: APVV Project LPP-0131-06

Schedule: 2007–2010

Role: Other investigator

Title: Novel DNA intercalators on the basis of proflavine pharmacophore and acridine derivatives functionalized by peptide moiety possessing anticancer and antimicrobial properties.

Founding: VEGA č. 1/0053/08 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2008–2010

Role: Principal investigator

Title: Training of teachers of chemistry and science to selected topics of sustainable development through "blended learning".

Founding: KEGA č.3/6301/08 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2008–2010

Role: Other investigator

Title: Biochemical nomenclature.

Founding: KEGA č. 083-006UPJŠ-4/2010 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2010

Role: Principal investigator

Title: Design and implementation of digital libraries for teaching cross-cutting themes of the State educational program

Founding: KEGA Ministry of Education, Science, Research and Sport of the SR

Schedule: 2011–2013

Role: Deputy investigator

Title: Alternative structural motives in DNA regulating regions: mutagenesis, chromosomal rearrangements and genetic diseases

Founding: VEGA č.1/0153/09 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2009–2011

Role: Other investigator

Title: Modulators of cellular thiols with DNA-binding activity - preparation and screening of new multitarget substances possessing anticancer properties.

Founding: VEGA č. 1/0097/10 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2010–2011

Role: Deputy investigator

Title: Occurrence, structural variability and biological role of G-quadruplex in the genome of mammalian viruses.

Founding: VEGA 1/0504/12 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2012–2014

Role:Other investigator

Title: Selfassembling the G-DNA structures as starting materials for molecular nanodevices.

Founding: APVV-0280-11

Schedule:2012–2015

Role:Other investigator

Title: Target cholinesterase and topoisomerase inhibitors as anti-Alzheimer´s drugs and cytostatic chemotherapeutics.

Founding: VEGA č. 1/0001/13 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2013–2016

Role: Principal investigator

Title: G-kvadruplexy odvodené od vírusov: využitie ich vlastností v biomedicínskom výskume. 

Founding: VEGA č. 1/0131/16 Ministry of Education, Science, Research and Sport of the SR 

Schedule: 2016–2019 

Role: Other investigator

Title: Štúdium cytotoxickej aktivity nových kumarínových derivátov modifikovanými akridínovým, takrínovým a antracénovým skeletom. 

Founding: VEGA č. 1/0016/18 Ministry of Education, Science, Research and Sport of the SR

Schedule: 2018–2021 

Role: Principal investigator

Cooperation

• Institute of Biophysics, Department of Molecular Biophysics and Pharmacology, Academy of Science of the Czech Republic, Brno, Czech Republic.
• Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.
• Biomedical Research Center, University Hospital Hradec Králove, Hradec Králové, Czech Republic.
• Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Moyzesova 11, 040 01 Košice, Slovak Republic.
• University of Hradec Králové, Faculty of Science, Department of Chemistry, Czech Republic.
• Department of Medical and Clinical Biochemistry, P. J. Šafárik University, Slovak Republic.
• Faculty of chemical and food technology, Slovak University of technology in Bratislava, Slovak Republic.
• Department of Biophysics, Institute of Experimental Physics, Košice, Slovak Republic.
• University of Pécs, Medical School, Institute of Pharmaceutical Chemistry.

Student supervising and educational activities

Bc. degree – 32

Dissertation Mgr. – supervisor – 43

RNDr. – supervisor – 11

PhD. degree, supervisor/supervisor-specialist – 5

Publication activity

Author or co-author of 47 original articles with IF

Author or co-author of 10 book chapters

H-index: 15

(dated 5/2021)

Selected Publications

2021

Mária Kožurková,  Danica Sabolová, Pavol Kristian: A new look at 9-substituted acridines with various biological activities. Journal of applied toxicology. - ISSN 0260-437X, Vol. 41 (2021) s. 175-189.

Eva Konkoľová,  Monika Hudáčová, Slávka Hamuľaková,  Rastislav Jendželovský,  Jana Vargová, Juraj Ševc, Peter Fedoročko, Mária Kožurková:  Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines. Molecules. ISSN 1420-3049, Vol. 26, (2021) art.no. 1133, s. 1-13.

Monika Hudáčová, Slávka Hamuľaková, Eva Konkoľová,  Rastislav Jendželovský,  Jana Vargová, Juraj Ševc, Peter Fedoročko, Ondrej Soukup, Jana Janočková, Veronika Ihnátová, Tomáš Kučera, Petr Bzonek, Nikola Nováková, Daniel Jun, Lucie Junová, Ján Korabečný, Kamil Kuča, Mária Kožurková: Synthesis of new biscomarin derivatives, in vitro cholinesterase inhibition, molecular modelling and antiproliferative effect in A549 human lung carcinoma cells. International Journal of Molecular Science. ISSN 1422-0067, Vol. 22 (2021) 3830 s. 1-21.

2020

Patrik Nunhart,  Eva Konkoľová,  Ladislav Janovec,  Jana Kašpárková, Jaroslav Malina, Viktor Brabec, Mária Matejová, Beáta Miltáková, Ladislav Novotný, Oludotun A. Phillips, Edet Udo, Mária Kožurková: Antimicrobial activity and DNA/HSA interaction of fluorinated 3,6,9-trisubstituted acridines. Chemical Papers. ISSN 2585-7290. Vol. 74, (2020), s. 2327-2337.

Patrik Nunhart,  Eva Konkoľová,  Ladislav Janovec,  Rastislav Jendželovský,  Jana Vargová, Juraj Ševc, Mária Matejová, Beáta Miltáková, Peter Fedoročko, Mária Kožurková:  Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity. Bioorganic chemistry. ISSN 0045-2068, Vol. 94 (2020), art.no. 103393, s. 1-12.

Danica Sabolová, Pavol Kristian,Mária Kožurková: Proflavine/acriflavine derivatives with versatile biological activities. Journal of Applied Toxicology, ISSN 0260-437X, Vol. 40 (2020), s. 64-71.

2019

Ladislav Janovec, Jana Janočková, Mária Matejová, Eva Konkoľová, Helena Paulíková, Daniela Lichancová, Lenka Júnošová, Slávka Hamuľaková, Ján Imrich, Mária Kožurková: Proliferation inhibition of novel diphenylamino derivatives. Bioorganic Chemistry, ISSN 0045-2068, Vol. 83, (2019), s. 487- 499.

Jana Janočková, Ján Korabečný, Jana Plšíková, Kateřina Babková, Eva Konkoľová, Dana Kučerová, Jana Vargová, Peter Fedoročko, Jana Kašpárková, Viktor Brabec, Ján Rosocha, Ondrej Soukup, Slávka Hamuľaková, Kamil Kuča, Mária Kožurková: In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers. Journal of Enzyme Inhibition and Medicinal Chemistry. - ISSN 1475-6366. - Roč. 34, č. 1 (2019), s. 877-897.

2018

Lucia Krajňáková, Jana Pisarčíková, Ladislav Drajna, Martina Labudová, Ján Imrich, Helena Paulíková, Mária Kožurková: Intracellular distribution of new tacrine analogues as a potential cause of their cytotoxicity against human neuroblastoma cells SH-SY5Y. Medicinal Chemistry Research : an international journal for rapid communications on design and mechanisms of action of biologically active agents. - ISSN 1054-2523. - Roč. 27, č. 10 (2018), s. 2353-2365.

Danica Sabolová, Pavol Kristian, Mária Kožurková: Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity. Journal of Applied Chemistry. Vol. 11 (2018), s. 1377-1387.

Eva Konkoľová, Jana Janočková, Pál Perjési, Janka Vašková, Mária Kožurková: Selected ferrocenyl chalcones as DNA/BSA-interacting agents and inhibitors of DNA topoisomerase I and II activity. Journal of Organometallic Chemistry, ISSN 0022-328X, Vol. 861 (2018), s. 1-9.

Othman Salem, Mária Kožurková: Sulfur containing acridine derivatives in preclinical studies with cancer cell lines. Current Medicinal Chemistry, ISSN 0929-8673, Vol. 25, no. 17 (2018), s. 1968-1975.

2017

Michal Bečka, Mária Vilková, Othman Salem, Jana Kašpárková, Viktor Brabec, Mária Kožurková:  3-[(E)-(acridin-9'-ylmethylidene)amino]-1-substituted thioureas and their biological activity. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, Vol. 180 (2017), s. 234-241.

Mária Kožurková, Danica Sabolová, Pavol Kristian: A review on acridinyl-thioureas and its derivatives: biological and cytotoxic activity. Journal of Applied Toxicology, ISSN 0260-437X, Vol. 37, no. 10 (2017), s. 1132-1139.

Slávka Hamuľaková, Mária Kožurková, Kamil Kuča: Coumarin derivatives in pharmacotherapy of Alzheimer´s disease. Current Organic Chemistry, ISSN 1385-2728, Vol. 21, no. 7 (2017), s. 602-612.

Lucia Andrezálová, Jana Plšíková, Jana Janočková, Katarína Koňariková, Ingrid Žitňanová, Mária Kohútová, Mária Kožurková: DNA/BSA binding ability and genotoxic effect of mono- and binuclear copper (II) complexes containing a Schiff base derived from salicylaldehyde and D, L-glutamic acid. Journal of Organometallic Chemistry, ISSN 0022-328X, Vol. 827 (2017), s. 67-77.

Othman Salem, Mária Vilková, Jana Janočková, Rastislav Jendželovský, Peter Fedoročko, Ján Imrich, Mária Kožurková: Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives: Medicinal Chemistry Research, ISSN 1054-2523, Vol. 26, no. 10 (2017), s. 2309-2321.

2016

Jana Janočková, Eva Žilecká, Jana Kašpárková, Viktor Brabec, Ondřej Soukup, Kamil Kuča, Mária Kožurková: Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity. Molecular BioSystems, ISSN 1742-206X, Vol. 12, no. 9 (2016), s. 2910-2920.

Othman Salem, Mária Vilková, Jana Janočková, Rastislav Jendželovský, Peter Fedoročko, Eva Žilecká, Jana Kašpárková, Viktor Brabec, Ján Imrich, Mária Kožurková: New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds. International Journal of Biological Macromolecules, ISSN 0141-8130, Vol. 86 (2016), s. 690-700.

2015

Andrea Ševčovičová, Martina Šemeláková, Jana Plšíková, Dušan Loderer, Petronela Imreová, Eliška Gálová, Mária Kožurková, Eva Miadoková, Peter Fedoročko: DNA-protective activities of hyperforin and aristoforin. Toxicology in Vitro, ISSN 0887-2333, Vol. 29, no. 3 (2015), s. 631-637.

Jana Janočková, Jana Plšíková, Jana Kašpárková, Viktor Brabec, Rastislav Jendželovský, Jaromír Mikeš, Ján Kovaľ, Slávka Hamuľaková, Peter Fedoročko, Kamil Kuča, Mária Kožurková: Inhibition of DNA topoisomerases I and II and growth inhibition of HL-60 cells by novel acridine-based compounds. European Journal of Pharmaceutical Sciences, ISSN 0928-0987, Vol. 76 (2015), s. 192-202.

Jana Janočková, Jana Plšíková, Ján Kovaľ, Rastislav Jendželovský, Jaromír Mikeš, Jana Kašpárková, Viktor Brabec, Slávka Hamuľaková, Peter Fedoročko, Mária Kožurková: Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors. Bioorganic Chemistry, ISSN 0045-2068, Vol. 59 (2015), s. 168-176.

2014

Jana Janočková, Zuzana Guľašová, Jana Plšíková, Kamil Musilek, Kamil Kuča, Jaromír Mikeš, Ľubomír Čulka, Peter Fedoročko, Mária Kožurková: Interaction of cholinesterase modulators with DNA and their cytotoxic activity. International Journal of Biological Macromolecules, ISSN 0141-8130, Vol. 64 (2014), s. 53-62.

Jana Plšíková, Jana Štěpánková, Jana Kašpárková, Viktor Brabec, Martin Bačkor, Mária Kožurková: Lichen secondary metabolites as DNA-interacting agents. Toxicology in Vitro, ISSN 0887-2333, Vol. 28, no. 2 (2014), s. 182-186.

Slávka Hamuľaková, Ján Imrich, Ladislav Janovec, Pavol Kristian, Ivan Danihel, Ondrej Holas, Miroslav Pohanka, Stanislav Böhm, Mária Kožurková, Kamil Kuča: Novel tacrine/acridine anticholinesterase inhibitors with piperazine and thiourea linkers. International Journal of Biological Macromolecules, ISSN 0141-8130, Vol. 70 (2014), s. 435-439.

Ján Ungvarský, Jana Plšíková, Ladislav Janovec, Ján Kovaľ, Jaromír Mikeš, Lucia Mikešová, Denisa Hatvanová, Peter Fedoročko, Pavol Kristian, Jana Kašparková, Voktor Brabec, Mária Vojtičková, Danica Sabolová, Zuzana Stramová, Ján Rosocha, Ján Imrich, Mária Kožurková: Novel trisubstituted acridines as human telomeric quadruplex binding ligands. Bioorganic Chemistry, ISSN 0045-2068, Vol. 57 (2014), s.13-19.

2013

Jana Janočková, Zuzana Guľašová, Kamil Musilek, Kamil Kuča, Mária Kožurková: Novel cholinesterase modulators and their ability to interact with DNA. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, Vol. 115 (2013), s. 364-369.

2012

Jana Plšíková, Ladislav Janovec, Ján Kovaľ, Ján Ungvarský, Jaromír Mikeš, Rastislav Jendželovský, Peter Fedoročko, Ján Imrich, Pavol Kristian, Jana Kašpárková, Viktor Brabec, Mária Kožurková: 3,6-Bis(3-alkylguanidino) acridines as DNA-intercalating antitumor agents. European Journal of Medicinal Chemistry, ISSN 0223-5234, Vol. 57 (2012), s. 283-295.

Helena Paulíková, Zuzana Vantová, Ľubica Hunáková, Lýdia Čižeková, Mária Čarná, Mária Kožurková, Danica Sabolová, Pavol Kristian, Slávka Hamuľaková, Ján Imrich: DNA binding acridine-thiazolidine agents affecting intracellular glutathione. Bioorganic & Medicinal Chemistry, ISSN 0968-0896, Vol. 20, no. 24 (2012), s. 7139-7148.

2011

Ladislav Janovec, Mária Kožurková, Danica Sabolová, Ján Ungvarský, Helena Paulíková, Jana Plšíková, Zuzana Vantová, Ján Imrich: Cytotoxic 3,6-bis((imidazolidinone)imino)acridines: Synthesis, DNA binding and molecular modeling. Bioorganic & Medicinal Chemistry, ISSN 0968-0896, Vol. 19, no. 5 (2011), s. 1790-1801.

Danica Sabolová, Mária Kožurková, Tomáš Plichta, Zuzana Ondrušová, Daniela Hudecová, Martin Šimkovič, Helena Paulíková, Aladár Valent: Interaction of a copper(II)-Schiff base complexes with calf thymus DNA and their antimicrobial activity. International Journal of Biological Macromolecules, ISSN 0141-8130, Vol. 48, no. 2 (2011), s. 319-325.

Miroslava Štefanišinová, Vladimíra Tomečková, Mária Kožurková, Alexander V. Ostró, Mária Mareková: Study of DNA interactions with cyclic chalcone derivatives by spectroscopic techniques. Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy, ISSN 1386-1425, Vol. 81, no. 1 (2011), 666-671.

Mária Kožurková, Slávka Hamuľaková, Zuzana Gažová, Helena Paulíková, Pavol Kristian: Neuroactive multifunctional tacrine congeners with cholinesterase, anti-amyloid aggregation and neuroprotective properties. Pharmaceuticals, ISSN 1424-8247, Vol. 4, no. 2 (2011), s. 382-418.

2010

Zdenka Bedlovičová, Ján Imrich, Pavol Kristian, Ivan Danihel, Stanislav Böhm, Danica Sabolová, Mária Kožurková, Helena Paulíková, Karel D. Klika: Novel carbohydrazide and hydrazone biomarkers based on 9-substituted acridine and anthracene fluorogens. Heterocycles, ISSN 0385-5414, Vol. 80, no. 2 (2010), p. 1047-1066.