Kožurková Mária
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Visiting Professor
maria.kozurkova@upjs.sk
Maria obtained her degree as Associate Professor in 2008 at the P.J.Šafárik University. Currently she is responsible for the investigation of interaction of new drugs with DNA by various techniques. Besides the scientific activity, Maria is devoted to the students supervising and teaching. She is study consultant for Biochemistry.
Education
| Assoc. prof. |
(2008) |
Biochemistry - Faculty of Sciences, P.J. Šafárik University |
| CSc./Ph.D. |
(1993) |
General biology - Faculty of Sciences, P.J. Šafárik University |
| RNDr. |
(1987) |
Inorganic chemistry - Faculty of Sciences, P.J. Šafárik University |
Research Focus
Interaction of small molecules with biomolecules.
Professional Training
|
2003–today
|
Research - Institute of Biology, Faculty of Sciences, P.J. Šafárik University
|
|
1987–2003
|
Research a lecture - Department of Biochemistry,
Institute of Chemistry, Faculty of Science, P.J. Šafárik University
|
Membership in Scientific Organizations and Councils
- Slovak Society for Biochemistry and Molecular Biology
- Member of the National selection committee CEEPUS (central European Exchange Programme for University Studies)
- Association of Chemistry Teachers
Projects
Title: Štúdium latentného poškodenia pečene vyvolaného ožarovaním a chemickou noxou a hľadanie možností zmiernenia poškodenia podávaním hepatoprotektívnych látok.
Founding: VEGA č. 1/239/92 Ministry of Education, Science, Research and Sport of the SR
Schedule: 1992–1995
Role: Other investigator
Title: Účinok kombinovaného pôsobenia genotoxických činiteľov životného prostredia na pečeň a obličky.
Founding: VEGA č. 3228/96 Ministry of Education, Science, Research and Sport of the SR
Schedule: 1996–1998
Role: Other investigator
Title: Účinok niektorých genotoxických činiteľov životného prostredia na pečeň a obličky.
Founding: VEGA č. 1/6030/99 Ministry of Education, Science, Research and Sport of the SR
Schedule: 1999–2001
Role: Other investigator
Title: Transgeneračný prenos poškodenia genómu spôsobeného genotoxickými faktormi životného prostredia.
Founding: VEGA č. 1/6030/02 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2002–2004
Role: Other investigator
Title: Interaction of anticancer drugs with nucleic acids.
Founding: VEGA č. 1/1274/04 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2004–2006
Role: Other investigator
Title: Nestabilita genómu v mozgovom tkanive potomkov potkaních samcov exponovaných niektorými genotoxickými činiteľmi životného prostredia.
Founding: VEGA č. 1/2353/05 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2005–2007
Role: Other investigator
Title: Nové technológie vo výučbe chémie a biológie u žiakov základných a stredných škôl k trvalo udržateľnému rozvoju.
Founding: KEGA č. 3/3004/05 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2005–2007
Role: Other investigator
Title: Molecular design of new DNA binding anticancer and antibacterial drugs.
Founding: VEGA č. 1/3254/06 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2006–2008
Role: Other investigator
Title: Increasing of knowledge potential.
Founding: APVV Project LPP-0131-06
Schedule: 2007–2010
Role: Other investigator
Title: Novel DNA intercalators on the basis of proflavine pharmacophore and acridine derivatives functionalized by peptide moiety possessing anticancer and antimicrobial properties.
Founding: VEGA č. 1/0053/08 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2008–2010
Role: Principal investigator
Title: Training of teachers of chemistry and science to selected topics of sustainable development through "blended learning".
Founding: KEGA č.3/6301/08 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2008–2010
Role: Other investigator
Title: Biochemical nomenclature.
Founding: KEGA č. 083-006UPJŠ-4/2010 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2010
Role: Principal investigator
Title: Design and implementation of digital libraries for teaching cross-cutting themes of the State educational program
Founding: KEGA Ministry of Education, Science, Research and Sport of the SR
Schedule: 2011–2013
Role: Deputy investigator
Title: Alternative structural motives in DNA regulating regions: mutagenesis, chromosomal rearrangements and genetic diseases
Founding: VEGA č.1/0153/09 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2009–2011
Role: Other investigator
Title: Modulators of cellular thiols with DNA-binding activity - preparation and screening of new multitarget substances possessing anticancer properties.
Founding: VEGA č. 1/0097/10 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2010–2011
Role: Deputy investigator
Title: Occurrence, structural variability and biological role of G-quadruplex in the genome of mammalian viruses.
Founding: VEGA 1/0504/12 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2012–2014
Role:Other investigator
Title: Selfassembling the G-DNA structures as starting materials for molecular nanodevices.
Founding: APVV-0280-11
Schedule:2012–2015
Role:Other investigator
Title: Target cholinesterase and topoisomerase inhibitors as anti-Alzheimer´s drugs and cytostatic chemotherapeutics.
Founding: VEGA č. 1/0001/13 Ministry of Education, Science, Research and Sport of the SR
Schedule: 2013–2016
Role: Principal investigator
Cooperation
- Institute of Biophysics, Department of Molecular Biophysics and Pharmacology, Academy of Science of the Czech Republic, Brno, Czech Republic.
- Faculty of Pharmacy, Charles University, Hradec Kralove, Czech Republic.
- Biomedical Research Center, University Hospital Hradec Králove, Hradec Králové, Czech Republic.
- Department of Cellular Biology, Institute of Biology and Ecology, Faculty of Science, P. J. Šafárik University in Košice, Moyzesova 11, 040 01 Košice, Slovak Republic.
- University of Hradec Králové, Faculty of Science, Department of Chemistry, Czech Republic.
- Department of Medical and Clinical Biochemistry, P. J. Šafárik University, Slovak Republic.
- Faculty of chemical and food technology, Slovak University of technology in Bratislava, Slovak Republic.
- Department of Biophysics, Institute of Experimental Physics, Košice, Slovak Republic.
Student supervising and educational activities
Bc degree - supervisor
Lucia Lichardusová, 2006
Štefánia Kozaková, 2006
Mária Horvátová, 2006
Miroslava Štefanišinová, 2006
Jana Plšíková, 2007
Michaela Michalcová, 2007
Eva Tešinská, 2008
Mária Lalkovičová, 2008
Lýdia Čížeková, 2008
Anna Adamcová, 2008
Veronika Fečuová, 2008
Veronika Kováčová, 2008
Lucia Balážová, 2008
Gabriel Bódy, 2009
Miroslava Droppová, 2009
Ján Fiala, 2009
Jana Janočková, 2009
Matúš Čoma, 2011
Jana Vargová, 2011
Martina Brudňáková, 2012
Veronika Oravcová, 2013
Miroslava Ščerbáková, 2013
Tatiana Kačmareková, 2013
Mária Kuzmiaková, 2014
Nikola Horváthová, 2014
Dissertation – Mgr., supervisor
Renáta Sklenková, 1993
Hanka Liptáková, 1995
Jana Stašáková, 1995
Zuzna Sedláková, 1996
Vladislav Cucak, 2003
Eva Bugárová, 2004
Lucia Letavayová, 2004
Ján Šterba, 2004
Martina Dvorščáková, 2005
Ján Kovaľ, 2005
Petra Kravčuková, 2005
Rastislav Jendželovský, 2005
Ivana Rondzíková, 2005
Jana Žiaranová, 2005
Jana Lisoňová, 2006 - supervisor - specialist
Jana Sabová, 2006
Jana Sviatkovská, 2007
Zuzana Vantová, 2007
Tomáš Plichta, 2008
Miroslava Štefanišinová, 2008
Michaela Michalcová, 2009
Lucia Balážová, 2010
Anna Čačková, 2010
Jana Janočková, 2011
Ján Fiala, 2011.
Othman M. Salem, 2011
Zuzana Gulášová, 2012
Monika Bazelóvá, 2012
Zuzana Gulášová, 2012
Jana Vargová, 2013
Eva Žilecká, 2014
RNDr. - supervisor
Vladislav Cucak, 2003
Lenka Boberová, 2005
Ivana Rondzíková, 2005
Jana Žiaranová, 2006
Jana Lisoňová, 2007
Janka Sviatkovská, 2008
Jozef Maršičin, 2010
Zuzana Varchulová Nováková, 2011
Ján Fiala, 2012
Michaela Semančíková, 2012
Final thesis
Jana Žatkuliaková, 2009
PhD degree, supervisor /supervisor-specialist
Miroslava Štefanišinová, supervisor-specialist, 2009
Jana Plšíková, supervisor, 2012
Jana Janočková, supervisor (August, 2015)
Othamn Salem, supervisor (August, 2016)
Eva Žilecká, supervisor (August, 2017)
Publication activity
Author or co-author of 27 original articles with IF
Author or co-author of 9 book chapters
H-index: 8
(dated 1/2015)
Selected Publications
1992
Kožurková Mária, Kropáčová Katarína, Mišúrová Eva, Rexa Radimír: Effect of hepatoprotective agents thioctacid and flavobion on histones in the intact and regenerating liver of irradiated rats. Bulletin of Experimental Biology and Medicine. 113 (1992) 252-255.
1993
Kožurková Mária, Mišúrová Eva, Kropáčová Katarína: Aging and radiation induced alterations of histones in regenerating rat liver. Mechanisms of Ageing and Development. 72 (1993) 37-48.
1994
Kožurková Mária, Mišúrová Eva, Kropáčová Katarína: Aging and radiation induced alterations in liver histones. Neoplasma. 41, 2 (1994) 89-94.
Kožurková Mária, Haková Hedviga, Mišúrová Eva: The effect of silymarin, a hepatoprotective substance, on liver histones in irradiated rats. Veterinární Medicína (Praha). 39 (1994) 85-92.
1995
Kožurková Mária, Mišúrová Eva, Kropáčová Katarína: Effect of aging and gamma radiation on acetylation of rat liver histones. Mechanisms of Ageing and Development. 78 (1995) 1-14.
2006
Sabolová Danica, Kožurková Mária, Kristian Pavol, Danihel Ivan, Podhradský Dušan, Imrich Ján: Determination of the binding affinities of plasmid DNA using fluorescent intercalarors possessing an acridine skeleton. International Journal of Biological Macromolecules. 38 (2006) 94-98.
2008
Janovec Ladislav, Sabolová Danica, Kožurková Mária, Paulíkova Helena, Kristian Pavol, Ungvarský Ján, Moravčíkova Eva, Bajdichová Mária, Podhradský Dušan, Imrich Ján.: Synthesis, DNA interaction, and cytotoxic activity of a novel proflavine-dithiazolidinone pharmacophore. Bioconjugate Chemistry. 18 (2007) 93-100.
Kožurková Mária, Letavayová Lucia, Mišúrová Eva: Influence of gamma irradiation on the level of DNA methylation in liver of male rats and their offspring. Acta Veterinaria Brno. 76 (2007) 215-222.
Kožurková Mária, Sabolová Danica, Janovec Ladislav, Kristian Pavol, Bajdichová Mária, Buša Ján, Podhradský Dušan, Imrich Ján: DNA binding properties and evaluation of cytotoxic activity of 9,10-bis-N-substituted (aminomethyl)anthracenes. International Journal of Biological Macromolecules. 41 (2007) 415-422.
2008
Kožurková Mária, Sabolová Danica, Janovec Ladislav, Mikeš Jaromír, Kovaľ Ján, Ungvarský Ján, Štefanišinová Miroslava, Fedoročko Peter, Kristian Pavol, Imrich Ján: Cytotoxic activities of proflavine ureas: Synthesis, antitumor evaluation and DNA binding properties of 1´,1´´-(acridine-3,6-diyl)- 3´,3´´-dialkyl-ureas. Bioorganic and Medicinal Chemistry. 16 (2008) 3976-3984.
2009
Fröhlichová Zdenka, Tomaščiková Jana, Imrich Ján, Kristian Pavol, Danihel Ivan, Böhm Stanislav, Sabolová Danica, Kožurková Mária, Klika Karel D.: Synthesis and properties of novel biologically interesting polycyclic 1,3,4-oxadiazoles containing acridine/acridone moieties. Heterocycles. 77 (2009) 1019-1035.
Vantová Zuzana, Paulíková Helena, Sabolová Danica, Kožurková Mária, Sucháňová Mária, Janovec Ladislav, Kristian Pavol, Imrich Ján: Cytotoxic activity of acridin-3,6-diyl dithiourea hydrochlorides in human leukemia line HL60 and in resistant subline HL60/ADR. International Journal of Biological Macromolecules. 45 (2009) 174-180.
Fröhlichová Zdenka, Imrich Ján, Danihel Ivan, Kristian Pavol, Böhm Stanislav, Sabolová Danica, Kožurková Mária, Hritzová Oľga, Horváth Branislav, Bušová Tatiana, Klika Karel D.: Spectroscopic, structural and theoretical studies of novel, potentially cytotoxic 4-acridonecarboxamide imines. Spectrochimica Acta Part A. Molecular and Biomolecular Spectroscopy. 73 (2009) 238-248.
2010
Bedlovičová Zdenka, Imrich Ján, Kristian Pavol, Danihel Ivan, Böhm Stanislav, Sabolová Danica, Kožurková Mária, Pauliková Helena, Klika Karel D.: Novel carbohydrazide and hydrazone biomarkers based on 9-substituted acridine and anthracene fluorogens. Heterocycles. 80 (2010) 1047-1066.
2011
Ladislav Janovec, Maria Kožurková, Danica Sabolová, Ján Ungvarský Helena Paulíková, Jana Plšíková, Zuzana Vantová, Ján Imrich: Cytotoxic 3,6-bis((imidazolidinone) imino)acridines: Synthesis, DNA binding and molecular modeling. Bioorganic and Medicinal Chemistry. 19 (2011) 1790-1801.
Danica Sabolová, Mária Kožurková, Tomáš Plichta, Zuzana Ondrušová, Daniela Hudecová, Miroslav Šimkovič, Helena Paulíková, Aladár Valent: Interaction of a Copper(II)-Schiff base complexes with calf thymus DNA and their antimicrobial activity. International Journal of Biological Macromolecules. 48 (2011) 319-325.
Miroslava Štefanišinová, Vladimíra Tomečková, Mária Kožurková, Alexander Ostró, Mária Mareková: DNA interactions with cyclic chalcone derivatives. Spectrochimica Acta Part A. Molecular and Biomolecular Spectroscopy. 81 (2011) 666-671.
2012
Jana Plšíková, Ladislav Janovec, Ján Kovaľ, Ján Ungvarsky, Jaromir Mikes, Rastislav Jenželovsaký, Peter Fedorocko, Ján Imrich, Pavol Kristian, Jana Kašpárková, Viktor Brabec, Mária Kožurková: 3,6-bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents. European Journal of Medicinal Chemistry. 57 (2012) 283-295.
Paulíková Helena, Vantová Zuzana, Hunáková Ľuba, Čizeková Lýdia, Čarná Mária, Kožurková Mária, Sabolová Danica, Kristian Pavol, Hamuľaková Slávka, Imrich Ján: DNA binding acridine-thiazolidinone agents affecting intracellular glutathione. Bioorganic and Medicinal Chemistry. 20 (2012) 7139-7148.
2013
Jana Janockova, Zuzana Gulasova, Kamil Musilek, Kamil Kuca, Maria Kozurkova: Novel cholinesterase modulators and their ability to interact with DNA. Spectrochimica Acta Part A. Molecular and Biomolecular Spectroscopy 115 (2013) 364-369.
2014
Jana Plsíkova, Jana Stepankova, Jana Kasparkova, Viktor Brabec, Martin Backor, Maria Kozurkova: Lichen secondary metabolites as DNA-interacting agents. Toxicology in vitro, 28 (2014) 182-186.
Jana Janockova, Zuzana Gulasova, Jana Plsikova, Kamil Musilek, Kamil Kuca, Jaromir Mikes, Lubomir Culka, Peter Fedorocko, Maria Kozurkova: Interaction of cholinesterase modulators with DNA and their DNA-related biological activity. International Journal of Biological Macromolecules 64 (2014) 53-62.
Slávka Hamuľáková, Ján Imrich, Ladislav Janovec, Pavol Kristian, Ivan Danihel, Ondrej Holas, Miroslav Pohanka, Stanislav Böhm, Mária Kožurková, Kamil Kuča: Novel bivalent tacrine/acridine acetylcholinesterase inhibitors with piperazine and thiourea linkers. International Journal of Biological Macromolecules 70 (2014) 435-439.
Jan Ungvarsky, Jana Plsikova, Ladislav Janovec, Jan Koval, Jaromir Mikes, Lucia Mikesova, Denisa Harvanova, Peter Fedorocko, Pavol Kristian, Jana Kašpárková, Viktor Brabec, Maria Vojtickova, Danica Sabolová, Zuzana Stramova, Jan Imrich, Maria Kozurkova: Novel trisubstitutes acridine as human telomeric quadruplex binding ligands. Bioorganic Chemistry 57 (2014) 13-29.
